Effect of intravenous pulses of methylprednisolone 250 mg versus dexamethasone 6 mg in hospitalised adults with severe COVID-19 pneumonia: An open-label randomised trial.

BACKGROUND: The efficacy and safety of high versus medium doses of glucocorticoids for the treatment of patients with COVID-19 has shown mixed outcomes in controlled trials and observational studies. We aimed to evaluate the effectiveness of methylprednisolone 250 mg bolus versus dexamethasone 6 mg in patients with severe COVID-19. METHODS: A randomised, open-label, controlled trial was conducted between February and August 2021 at four hospitals in Spain. The trial was suspended after the first interim analysis since the investigators considered that continuing the trial would be futile. Patients were randomly assigned in a 1:1 ratio to receive dexamethasone 6 mg once daily for up to 10 days or methylprednisolone 250 mg once daily for 3 days. RESULTS: Of the 128 randomised patients, 125 were analysed (mean age 60 ± 17 years; 82 males [66%]). Mortality at 28 days was 4.8% in the 250 mg methylprednisolone group versus 4.8% in the 6 mg dexamethasone group (absolute risk difference, 0.1% [95% CI, -8.8 to 9.1%]; p = 0.98). None of the secondary outcomes (admission to the intensive care unit, non-invasive respiratory or high-flow oxygen support, additional immunosuppressive drugs, or length of stay), or prespecified sensitivity analyses were statistically significant. Hyperglycaemia was more frequent in the methylprednisolone group at 27.0 versus 8.1% (absolute risk difference, -18.9% [95% CI, -31.8 to - 5.6%]; p = 0.007). CONCLUSIONS: Among severe but not critical patients with COVID-19, 250 mg/d for 3 days of methylprednisolone compared with 6 mg/d for 10 days of dexamethasone did not result in a decrease in mortality or intubation.

N-antigenemia detection by a rapid lateral flow test predicts 90-day mortality in COVID-19: A prospective cohort study.

OBJECTIVES: To evaluate if the detection of N antigen of SARS-CoV-2 in plasma by a rapid lateral flow test predicts 90-day mortality in COVID-19 patients hospitalized at the wards. METHODS: The presence of N-antigenemia was evaluated in the first 36 hours after hospitalization in 600 unvaccinated COVID-19 patients, by using the Panbio COVID-19 Ag Rapid Test Device from Abbott (Abbott Laboratories Inc., Chicago, IL, USA). The impact of N-antigenemia on 90-day mortality was assessed by multivariable Cox regression analysis. RESULTS: Prevalence of N-antigenemia at hospitalization was higher in nonsurvivors (69% (82/118) vs. 52% (250/482); p < 0.001). The patients with N-antigenemia showed more frequently RNAemia (45.7% (148/324) vs. 19.8% (51/257); p < 0.001), absence of anti-SARS-CoV-2 N antibodies (80.7% (264/327) vs. 26.6% (69/259); p < 0.001) and absence of S1 antibodies (73.4% (240/327) vs. 23.6% (61/259); p < 0.001). The patients with antigenemia showed more frequently acute respiratory distress syndrome (30.1% (100/332) vs. 18.7% (50/268); p = 0.001) and nosocomial infections (13.6% (45/331) vs. 7.9% (21/267); p = 0.026). N-antigenemia was a risk factor for increased 90-day mortality in the multivariable analysis (HR, 1.99 (95% CI,1.09-3.61), whereas the presence of anti-SARS-CoV-2 N-antibodies represented a protective factor (HR, 0.47 (95% CI, 0.26-0.85). DISCUSSION: The presence of N-antigenemia or the absence of anti-SARS-CoV-2 N-antibodies after hospitalization is associated to increased 90-day mortality in unvaccinated COVID-19 patients. Detection of N-antigenemia by using lateral flow tests is a quick, widely available tool that could contribute to early identify those COVID-19 patients at risk of deterioration.

Influencia del dióxido de nitrógeno ambientalen las consultas a urgencias por asma en un entorno con baja contaminación: análisis de series temporales y casos cruzados / Impact of atmospheric nitrogen dioxide on emergency department visits for asthma in a low air pollution area: a time series and case-crossover study

Objetivo: Analizar la asociación entre los niveles ambientales de dióxido de nitrógeno (NO2) y el número de consultas a urgencias por un episodio de agudización de asma bronquial en la población adulta de un entorno urbano con bajos niveles de contaminación. Método: Estudio ecológico retrospectivo de series temporales. Se consideraron las visitas por asma de pacientes mayores de 14 años que acudieron a un servicio de urgencias de forma consecutiva entre 2010 y 2018 (3.287 días). La asociación entre la concentración media de NO2 y el número diario de visitas a urgencias por asma se estudió mediante un modelo lineal generalizado con regresión de Poisson. Se evaluó el impacto en el riesgo individual mediante un análisis de casos cruzados. Se ajustó por las variables confusoras meteorológicas, se corrigió la estacionalidad mediante análisis de tendencias y se evaluaron tres lags temporales (0, 1 y 3 días). Resultados: Se analizaron 2.527 urgencias por asma correspondientes a 1.588 pacientes (edad media 51 ± 21 años, 70% mujeres). Hubo una asociación positiva significativa (riesgo relativo: RR = 1,056, IC 95%: 1,006-1,108; p < 0,05) entre la concentración de NO2 y un mayor riesgo de consulta a urgencias por asma a los 3 días. Un incremento de 10 μgr/m3 de NO2 explicó el 5,3% de las consultas (fracción atribuible: FA = 5,30, IC 95%: 0,60-9,75; p < 0,05). Conclusiones: El incremento de los niveles ambientales de NO2 se asocia con un mayor número de urgencias hospitalarias por exacerbación de asma en adultos en un entorno con baja contaminación. (AU)

Objectives: To analyze the association between atmospheric levels of nitrogen dioxide (NO2) and the number of visits by adults to an emergency department (ED) for exacerbated asthma in an urban area with low levels of air pollution. Material and methods: Retrospective ecological time-series study. We quantified ED visits for asthma by consecutive patients over the age of 14 years between 2010 and 2018 (3287 days). The association between the mean atmospheric concentration of NO2 and the number of daily visits to the ED for asthma was analyzed with generalized linear regression analysis (Poisson modeling). The impact of exposure on individual risk was assessed by crossover analysis of case periods. We adjusted for confounding meteorologic variables, potential variability due to seasonal changes was corrected by trend analysis, and 3 time lags were assessed (0, 1, and 3 days). Results: We analyzed 2527 asthma emergencies in 1588 patients (70% female) with a mean (SD) age of 51 (21) years. A significant positive association (relative risk, 1.056, 95% CI, 1.006-1.108; P .05) between atmospheric NO2 concentration and greater risk of visiting an ED within 3 days was detected. An increase of 10 µg/m3 of NO2 accounted for 5.3% of the visits (attributable fraction, 5.30, 95% CI, 0.60-9.75; P .05). Conclusion: In an urban area with low pollution levels, an elevation in atmospheric NO2 is associated with more hospital ED visits for asthma attacks in adults. (AU)

Impact of atmospheric nitrogen dioxide on emergency department visits for asthma in a low air pollution area: a time series and case-crossover study. / Influencia del dióxido de nitrógeno ambiental en las consultas a urgencias por asma en un entorno con baja contaminación: análisis de series temporales y casos cruzados.

OBJECTIVES: To analyze the association between atmospheric levels of nitrogen dioxide (NO2) and the number of visits by adults to an emergency department (ED) for exacerbated asthma in an urban area with low levels of air pollution. MATERIAL AND METHODS: Retrospective ecological time-series study. We quantified ED visits for asthma by consecutive patients over the age of 14 years between 2010 and 2018 (3287 days). The association between the mean atmospheric concentration of NO2 and the number of daily visits to the ED for asthma was analyzed with generalized linear regression analysis (Poisson modeling). The impact of exposure on individual risk was assessed by crossover analysis of case periods. We adjusted for confounding meteorologic variables, potential variability due to seasonal changes was corrected by trend analysis, and 3 time lags were assessed (0, 1, and 3 days). RESULTS: We analyzed 2527 asthma emergencies in 1588 patients (70% female) with a mean (SD) age of 51 (21) years. A significant positive association (relative risk, 1.056, 95% CI, 1.006-1.108; P .05) between atmospheric NO2 concentration and greater risk of visiting an ED within 3 days was detected. An increase of 10 µg/m3 of NO2 accounted for 5.3% of the visits (attributable fraction, 5.30, 95% CI, 0.60-9.75; P .05). CONCLUSION: In an urban area with low pollution levels, an elevation in atmospheric NO2 is associated with more hospital ED visits for asthma attacks in adults.

OBJETIVO: Analizar la asociación entre los niveles ambientales de dióxido de nitrógeno (NO2) y el número de consultas a urgencias por un episodio de agudización de asma bronquial en la población adulta de un entorno urbano con bajos niveles de contaminación. METODO: Estudio ecológico retrospectivo de series temporales. Se consideraron las visitas por asma de pacientes mayores de 14 años que acudieron a un servicio de urgencias de forma consecutiva entre 2010 y 2018 (3.287 días). La asociación entre la concentración media de NO2 y el número diario de visitas a urgencias por asma se estudió mediante un modelo lineal generalizado con regresión de Poisson. Se evaluó el impacto en el riesgo individual mediante un análisis de casos cruzados. Se ajustó por las variables confusoras meteorológicas, se corrigió la estacionalidad mediante análisis de tendencias y se evaluaron tres lags temporales (0, 1 y 3 días). RESULTADOS: Se analizaron 2.527 urgencias por asma correspondientes a 1.588 pacientes (edad media 51 ± 21 años, 70% mujeres). Hubo una asociación positiva significativa (riesgo relativo: RR = 1,056, IC 95%: 1,006-1,108; p 0,05) entre la concentración de NO2 y un mayor riesgo de consulta a urgencias por asma a los 3 días. Un incremento de 10 µgr/m3 de NO2 explicó el 5,3% de las consultas (fracción atribuible: FA = 5,30, IC 95%: 0,60-9,75; p 0,05). CONCLUSIONES: El incremento de los niveles ambientales de NO2 se asocia con un mayor número de urgencias hospitalarias por exacerbación de asma en adultos en un entorno con baja contaminación.

Modelos de riesgo para la predicción de mortalidad hospitalaria en ancianos con neumonía por COVID-19 / Mortality risk model for patients with suspected COVID-19 based on information available from an emergency dispatch center

Objetivo. Los objetivos son comparar la utilidad pronóstica de tres escalas de gravedad (Pneumonia Severity Index: PSI; CURB-65 scale; Severity Community Acquired Pneumonia Score: SCAP) y diseñar un nuevo modelo predictivo de mortalidad hospitalaria en pacientes mayores de 75 años ingresados por neumonía por COVID-19. Método. Estudio retrospectivo de pacientes mayores de 75 años ingresados por neumonía por COVID-19 desde el servicio de urgencias entre el 12 de marzo y el 27 de abril de 2020. Se recogieron variables demográficas (edad, sexo, institucionalización), clínicas (síntomas, comorbilidades, índice de Charlson) y analíticas (bioquímica en suero, gasometría, hematimetría, hemostasia). Se derivó un modelo de riesgo y se compararon las escalas de gravedad PSI, CURB-65 y SCAP para predecir la mortalidad intrahospitalaria por cualquier causa. Resultados. Se incluyeron 186 pacientes, con una mediana de edad de 85 años (RIC 80-89), un 44,1% varones. La mortalidad fue del 47,3%. Las escalas PSI, CURB-65 y SCAP tuvieron un área bajo la curva (ABC) de 0,74 (IC 95% 0,64-0,82), 0,71 (IC 95% 0,62-0,79) y 0,72 (IC 95% 0,63-0,81), respectivamente. El modelo predictivo compuesto por la ausencia o presencia de síntomas (tos y disnea), comorbilidad (índice de Charlson) y datos analíticos (aspartato-aminotransferasa, potasio, urea y lactato-deshidrogenasa) tuvo un ABC de 0,81 (IC 95% 0,73-0,88). Conclusión. Este estudio muestra que la escala PSI tiene una capacidad predictiva de mortalidad moderada, notablemente mejor que las escalas CURB-65 y SCAP. Se propone un nuevo modelo predictivo de mortalidad que mejora significativamente el rendimiento de estas escalas, siendo necesario verificar su validez externa. (AU)

Objectives: To compare the prognostic value of 3 severity scales: the Pneumonia Severity Index (PSI), the CURB-65 pneumonia severity score, and the Severity Community-Acquired Pneumonia (SCAP) score. To build a new predictive model for in-hospital mortality in patients over the age of 75 years admitted with pneumonia due to the coronavirus disease 2019 (COVID-19). Material and methods: Retrospective study of patients older than 75 years admitted from the emergency department for COVID-19 pneumonia between March 12 and April 27, 2020. We recorded demographic (age, sex, living in a care facility or not), clinical (symptoms, comorbidities, Charlson Comorbidity Index [CCI]), and analytical (serum biochemistry, blood gases, blood count, and coagulation factors) variables. A risk model was constructed, and the ability of the 3 scales to predict all-cause in-hospital mortality was compared. Results: We included 186 patients with a median age of 85 years (interquartile range, 80-89 years); 44.1% were men. Mortality was 47.3%. The areas under the receiver operating characteristic curves (AUCs) were as follows for each tool: PSI, 0.74 (95% CI, 0.64-0.82); CURB-65 score, 0.71 (95% CI, 0.62-0.79); and SCAP score, 0.72 (95% CI, 0.63-0.81). Risk factors included in the model were the presence or absence of symptoms (cough, dyspnea), the CCI, and analytical findings (aspartate aminotransferase, potassium, urea, and lactate dehydrogenase. The AUC for the model was 0.81 (95% CI, 0.73-0.88). Conclusion: This study shows that the predictive power of the PSI for mortality is moderate and perceptibly higher than the CURB-65 and SCAP scores. We propose a new predictive model for mortality that offers significantly better performance than any of the 3 scales compared. However, our model must undergo external validation. (AU)

Risk models for predicting in-hospital mortality from COVID-19 pneumonia in the elderly. / Modelos de riesgo para la predicción de mortalidad hospitalaria en ancianos con neumonía por COVID-19.

OBJECTIVES: To compare the prognostic value of 3 severity scales: the Pneumonia Severity Index (PSI), the CURB-65 pneumonia severity score, and the Severity Community-Acquired Pneumonia (SCAP) score. To build a new predictive model for in-hospital mortality in patients over the age of 75 years admitted with pneumonia due to the coronavirus disease 2019 (COVID-19). MATERIAL AND METHODS: Retrospective study of patients older than 75 years admitted from the emergency department for COVID-19 pneumonia between March 12 and April 27, 2020. We recorded demographic (age, sex, living in a care facility or not), clinical (symptoms, comorbidities, Charlson Comorbidity Index [CCI]), and analytical (serum biochemistry, blood gases, blood count, and coagulation factors) variables. A risk model was constructed, and the ability of the 3 scales to predict all-cause in-hospital mortality was compared. RESULTS: We included 186 patients with a median age of 85 years (interquartile range, 80-89 years); 44.1% were men. Mortality was 47.3%. The areas under the receiver operating characteristic curves (AUCs) were as follows for each tool: PSI, 0.74 (95% CI, 0.64-0.82); CURB-65 score, 0.71 (95% CI, 0.62-0.79); and SCAP score, 0.72 (95% CI, 0.63-0.81). Risk factors included in the model were the presence or absence of symptoms (cough, dyspnea), the CCI, and analytical findings (aspartate aminotransferase, potassium, urea, and lactate dehydrogenase. The AUC for the model was 0.81 (95% CI, 0.73-0.88). CONCLUSION: This study shows that the predictive power of the PSI for mortality is moderate and perceptibly higher than the CURB-65 and SCAP scores. We propose a new predictive model for mortality that offers significantly better performance than any of the 3 scales compared. However, our model must undergo external validation.

OBJETIVO: Los objetivos son comparar la utilidad pronóstica de tres escalas de gravedad (Pneumonia Severity Index: PSI; CURB-65 scale; Severity Community Acquired Pneumonia Score: SCAP) y diseñar un nuevo modelo predictivo de mortalidad hospitalaria en pacientes mayores de 75 años ingresados por neumonía por COVID-19. METODO: Estudio retrospectivo de pacientes mayores de 75 años ingresados por neumonía por COVID-19 desde el servicio de urgencias entre el 12 de marzo y el 27 de abril de 2020. Se recogieron variables demográficas (edad, sexo, institucionalización), clínicas (síntomas, comorbilidades, índice de Charlson) y analíticas (bioquímica en suero, gasometría, hematimetría, hemostasia). Se derivó un modelo de riesgo y se compararon las escalas de gravedad PSI, CURB-65 y SCAP para predecir la mortalidad intrahospitalaria por cualquier causa. RESULTADOS: Se incluyeron 186 pacientes, con una mediana de edad de 85 años (RIC 80-89), un 44,1% varones. La mortalidad fue del 47,3%. Las escalas PSI, CURB-65 y SCAP tuvieron un área bajo la curva (ABC) de 0,74 (IC 95% 0,64-0,82), 0,71 (IC 95% 0,62-0,79) y 0,72 (IC 95% 0,63-0,81), respectivamente. El modelo predictivo compuesto por la ausencia o presencia de síntomas (tos y disnea), comorbilidad (índice de Charlson) y datos analíticos (aspartato- aminotransferasa, potasio, urea y lactato-deshidrogenasa) tuvo un ABC de 0,81 (IC 95% 0,73-0,88). CONCLUSIONES: Este estudio muestra que la escala PSI tiene una capacidad predictiva de mortalidad moderada, notablemente mejor que las escalas CURB-65 y SCAP. Se propone un nuevo modelo predictivo de mortalidad que mejora significativamente el rendimiento de estas escalas, siendo necesario verificar su validez externa.

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19.

BACKGROUND: COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus. We studied whether viral RNAemia or viral RNA load in plasma is associated with severe COVID-19 and also to this dysregulated response. METHODS: A total of 250 patients with COVID-19 were recruited (50 outpatients, 100 hospitalized ward patients and 100 critically ill). Viral RNA detection and quantification in plasma was performed using droplet digital PCR, targeting the N1 and N2 regions of the SARS-CoV-2 nucleoprotein gene. The association between SARS-CoV-2 RNAemia and viral RNA load in plasma with severity was evaluated by multivariate logistic regression. Correlations between viral RNA load and biomarkers evidencing dysregulation of host response were evaluated by calculating the Spearman correlation coefficients. RESULTS: The frequency of viral RNAemia was higher in the critically ill patients (78%) compared to ward patients (27%) and outpatients (2%) (p < 0.001). Critical patients had higher viral RNA loads in plasma than non-critically ill patients, with non-survivors showing the highest values. When outpatients and ward patients were compared, viral RNAemia did not show significant associations in the multivariate analysis. In contrast, when ward patients were compared with ICU patients, both viral RNAemia and viral RNA load in plasma were associated with critical illness (OR [CI 95%], p): RNAemia (3.92 [1.183-12.968], 0.025), viral RNA load (N1) (1.962 [1.244-3.096], 0.004); viral RNA load (N2) (2.229 [1.382-3.595], 0.001). Viral RNA load in plasma correlated with higher levels of chemokines (CXCL10, CCL2), biomarkers indicative of a systemic inflammatory response (IL-6, CRP, ferritin), activation of NK cells (IL-15), endothelial dysfunction (VCAM-1, angiopoietin-2, ICAM-1), coagulation activation (D-Dimer and INR), tissue damage (LDH, GPT), neutrophil response (neutrophils counts, myeloperoxidase, GM-CSF) and immunodepression (PD-L1, IL-10, lymphopenia and monocytopenia). CONCLUSIONS: SARS-CoV-2 RNAemia and viral RNA load in plasma are associated with critical illness in COVID-19. Viral RNA load in plasma correlates with key signatures of dysregulated host responses, suggesting a major role of uncontrolled viral replication in the pathogenesis of this disease.

Cause-specific death in hospitalized individuals infected with SARS-CoV-2: more than just acute respiratory failure or thromboembolic events.

Infection with SARS-CoV-2 is becoming the leading cause of death in most countries during the 2020 pandemic. The objective of this study is to assess the association between COVID-19 and cause-specific death. The design is retrospective cohort study. We included data from inpatients diagnosed with COVID-19 between March 18 and April 21, 2020, who died during their hospital stay. Demographic, clinical and management data were collected. Causes of death were ascertained by review of medical records. The sample included 128 individuals. The median age was 84 (IQR 75-89), 57% were men. In 109 patients, the death was caused by SARS-CoV-2 infection, whereas in 19 (14.8%, 95 CI 10-22%), the infection acted only as a precipitating factor to decompensate other pathologies. This second group of patients was older (88y vs 82, p < 0.001). In age-adjusted analysis, they had a greater likelihood of heart failure (OR 3.61 95% CI 1.15-11.32), dependency in activities of daily living (OR 12.07 95% CI 1.40-103.86), frailty (OR 8.73 95% CI 1.37-55.46). The presence of X-ray infiltrates was uncommon (OR 0.07, 95% CI 0.02-0.25). A higher percentage of patient deaths from causes unrelated to COVID-19 complications occurred during the two first weeks of the pandemic. Fifteen percent of patients with COVID-19 infection died from decompensation of other pathologies and the cause of death was unrelated to COVID-19 severe complications. Most of these patients had more comorbidities and were frail and elderly. These findings can partially explain the excess mortality in older people.

Impacto del tiempo entre la extracción y el análisis de la gasometría arterial en la práctica clínica / The Effect Of Time Between Sample Extraction And Arterial Blood Gas Analysis In Clinical Practice

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Calidad de vida relacionada con la salud en trabajadores sanitarios / Health related quality of life in health workers

El estado de bienestar en que vivimos en los países desarrollados hace que surja la necesidad de buscar herramientas que sean una imagen fiel del estado de salud de la población como es la medición de la calidad de vida relacionada con la salud. El objetivo de nuestro estudio es conocer la calidad de vida relacionada con la salud (CVRS) de los trabajadores sanitarios como medida de su estado de salud. Para ello hemos realizado un estudio transversal, prospectivo y descriptivo de una muestra de 542 trabajadores seleccionada por muestreo sistemático. Como variable dependiente se evaluó la CVRS a través del cuestionario SF-36. Este cuestionario evalúa el estado de salud a través de 7 escalas (Función física, rol físico, salud general, vitalidad, función social, rol emocional y salud mental) valoradas de 0 a 100 (siendo 100 el mejor valor) y de dos dominios globales estandarizados para población general siendo su valor 50, (índice general de salud física e índice general de salud mental). Se tiene en cuenta la edad y el sexo para el análisis de los resultados. Los resultados más relevantes obtenidos son: Edad media 46 años (DE 10,4), 82% mujeres. Función física: 88.7 (Población general-PG-: 84.7); Rol físico: 86.5 (PG: 83.2); Dolor: 71.9 (PG: 79); Salud general: 70 (PG: 68.3); Vitalidad: 66.1 (PG: 66.9); Función social: 86.4 (PG: 90.1); Rol emocional: 87.8 (PG: 88.6); Salud mental: 72.6 (PG: 73). Índice global de salud física: 51.9; Índice global de salud mental: 49.8. Los valores encontrados tanto para las escalas de salud física como mental son ligeramente mejores que los establecidos para la población general para el mismo rango de edad y sexo, salvo en la escala de dolor (AU)

The welfare state in whom we live in the developed countries does that there arises the need to look for tools that are a faithful image of the health of the population such as it is the measurement of the quality of life related to the health. The aim of our study is to know the health related quality of life (HRQOL) of the sanitary workers as measure of their health status. For it we have realized a cross-sectional, prospective and descriptive study of a sample of 542 workers selected by systematic sampling. The dependent variable was assessed HRQOL by the SF-36. This questionnaire assesses the health status across 7 scales (physical function, role physical, general health, vitality, social function, emotional role and mental health) from 0 to 100 (100 being the best value) and two global domains standardized for general population value being 50, (general index of physical health, and general index of mental health). It takes into account the age and the sex for the analysis of the results. The most important results obtained are: Middle Age 46 years (SD 10,4), 82 % women. Physical function: 88.7 (PG-general population: 84.7), role physical, 86.5 (PG: 83.2); Pain 71.9 (PG 79), general health: 70 (PG: 68.3); Vitality: 66.1 (PG: 66.9 ), social function: 86.4 (PG: 90.1), Role emotional 87.8 (PG: 88.6); Mental Health: 72.6 (PG 73). Global index of physical health: 51.9; global Index of mental health: 49.8. The values found so much for the scales of physical as mental health are lightly better than the established ones for the general population for the same range of age and sex, except in the scale of pain (AU)

Influencia de las variables laborales en la presencia de morbilidad de los trabajadores sanitarios / Occupational influence of variables in the presence of morbidity of health workers

La información sobre la presencia de morbilidad en un colectivo de trabajadores podría ser una de las señas de identidad de las condiciones en las que se desempeña el trabajo. El objetivo es conocer el estado de salud en un colectivo de trabajadores sanitarios y los posibles factores laborales con los que pudiera estar relacionado. Para ello, se ha realizado un estudio transversal, prospectivo, descriptivo y analítico en una muestra de 554 trabajadores seleccionados por muestreo sistemático. Se incluyeron variables generales, hábitos saludables y tóxicos, variables laborales y presencia de morbilidad. Se ha realizado un análisis estadístico descriptivo y multivariante. Entre los resultados más relevantes conviene destacar que se trata de un colectivo de trabajadores de edad media de 46 años (DE: 10,4), 82% mujeres, sin actividad física (45%), fumadores (23%) y bebedores habituales (24%). La categoría más representada es la de enfermería (24%). Un 56% es personal fijo, con una antigüedad media de 14 años. Un 24% había sufrido accidentes de trabajo. Un 25% realiza turnos con diferencias significativas por categorías. Un 55% presenta alguna patología, siendo la osteomuscular la más prevalente (30%). En el análisis multivariante, la variable que mayor influencia ejerció sobre la morbilidad es la edad (OR: 1,04; IC 95%: 1.004-1.044). Respecto a las variables laborales, la única que ha mostrado relación independiente con la presencia de patología es la categoría y, concretamente, el colectivo de los celadores con la patología osteomuscular (OR: 2.685. IC 95%: 1,08-6,6) No se ha encontrado relación independiente del resto de variables estudiadas con la presencia de morbilidad (AU)

Information on the presence of disease in a group of workers could be one of the hallmarks of the conditions under which work is performed. We intended to know the health status in a group of health workers and possible job factors with which it may be related. We therefore performed a cross-sectional, prospective, descriptive, analytical study of a sample of 554 workers selected by systematic sampling. Variables included general, healthy habits and toxic industrial variables and presence of disease. Descriptive and multivariate statistical analysis. Among the most relevant results, it was a group of workers of average age 46 years (SD 10.4), 82% women, 45% no physical activity, smoking 23% and 24% regular drinkers. The most represented category was the nurses (24%). 56% permanent staff. Average age of 14. Accidents at work 24%. 25% were shifts with significant differences by category. 55% had some disease, being the most prevalent musculoskeletal (30%). In the multivariate analysisthe variable exerted the greatest influence on morbidity was age (OR: 1.04; 95% CI: 1,004-1,044). With regard to labor the only variable that showed an independent correlation with the presence of disease was more and more specifically the group of guards with musculoskeletal diseases (OR: 2,685; 95% CI: 1.08-6.6) No relationship was found independent of other variables the presence of disease (AU)

Estudio de obesidad en el medio sanitario / Study of obesity in workers ofa sanitary center

Hemos analizado a través de un estudio epidemiológico descriptivo con una muestra de 806 trabajadores, la prevalencia de sobrepeso/obesidad en un medio sanitario. Para ello utilizamos datos obtenidos de la historia clínico laboral de nuestros trabajadores y la obtención de datos antropométricos. Definimos como sobrepeso un IMC>25 y obesidad >30. Los resultados obtenidos en porcentajes generales de sobrepeso y obesidad son similares a los descritos en la literatura; por sexos, los hombres de la muestra presentan más obesidad que las mujeres a pesar de estandarizar por edad (en contra de lo publicado). Conclusiones: Existe una elevada prevalencia de obesidad/sobrepeso en nuestra muestra, al igual que en la población general, lo cual hace necesaria la participación del médico del trabajo desde los Servicios de Prevención para la identificación y seguimiento de los perfiles ponderales de los trabajadores y establecer estrategias adecuadas para reducir la prevalencia

We have analyzed through an epidemiological descriptive study with a sample of 806 workers, the prevalence of overweight / obesity in a sanitary way. For it we use information obtained of the history clinical labour of our workers and the obtaining of information anthropometrics. We define as overweight an IMC> 25 and obesity> 30. Them proved obtained in general percentages of overweight and obesity they are similar to described in the literature; for sexes, the men of the sample present more obesity than the women in spite of standardizing for age (against it published). Conclusions: A high prevalence of obesity / overweight exists in our sample, as in the general population, which makes necessary the participation of the doctor of the work from the Services of Prevention for the identification and follow-up of the perfilies consider them of the workers and to establish strategies adapted to reduce the prevalence